Humanin (human)

Humanin (human)
Bax inhibitor  
Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer's disease and by amyloid-β protein. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin. Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.
Product Specification
Sequence: H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH 
Formula: C119H204N34O32S2 
MW: 2687.3 
CAS: 330936-69-1 
Purity: ≥98% (HPLC) 
Appearance: White to off-white powder. 
Solubility: Soluble in DMSO or 5% acetic acid. 
Long Term Storage: -20°C

Company Name: PhtdPeptides. Co., Ltd.

Contact: William wang
Email: phtd012@phtdpeptides.com

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